Structure of PDB 2ibf Chain A Binding Site BS02

Receptor Information
>2ibf Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAA
VSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPY
SVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEV
VETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKE
LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQL
TSWDEDAW
Ligand information
>2ibf Chain D (length=19) Species: 623 (Shigella flexneri) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YEKAKEVSSALSKVLSKID
Receptor-Ligand Complex Structure
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PDB2ibf Vinculin binding in its closed conformation by a helix addition mechanism.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		M154 L157 V158 K162 G165 T169 K199 K210
Binding residue
(residue number reindexed from 1)		M154 L157 V158 K162 G165 T169 K199 K210
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ibf, PDBe:2ibf, PDBj:2ibf
PDBsum2ibf
PubMed17932491
UniProtP18206|VINC_HUMAN Vinculin (Gene Name=VCL)

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