Structure of PDB 2huo Chain A Binding Site BS02

Receptor Information

>2huo Chain A (length=258) Species: 10090 (Mus musculus)

FRNYTSGPLLDRVFTTYKLMHTHQTVDFVSRKRIQYGSFSYKKMTIMEAV
GMLDDLVDESDPDVDFPNSFHAFQTAEGIRKAHPDKDWFHLVGLLHDLGK
IMALWGEPQWAVVGDTFPVGCRPQASVVFCDSTFQDNPDLQDPRYSTELG
MYQPHCGLENVLMSWGHDEYLYQMMKFNKFSLPSEAFYMIRFHSFYPWHT
GGDYRQLCSQQDLDMLPWVQEFNKFDLYTKCPDLPDVESLRPYYQGLIDK
YCPGTLSW

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 2huo Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2huo Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): D124 H194 H220
• Binding residue (residue number reindexed from 1): D97 H167 H193
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.13.99.1: inositol oxygenase.

Gene Ontology

Molecular Function

• GO:0004033 aldo-keto reductase (NADPH) activity
• GO:0005506 iron ion binding
• GO:0008199 ferric iron binding
• GO:0016491 oxidoreductase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0046872 metal ion binding
• GO:0050113 inositol oxygenase activity

Biological Process

• GO:0019310 inositol catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0016234 inclusion body

External links

• PDB: RCSB:2huo, PDBe:2huo, PDBj:2huo
• PDBsum: 2huo
• PubMed: 17012379
• UniProt: Q9QXN5|MIOX_MOUSE Inositol oxygenase (Gene Name=Miox)