Structure of PDB 2huf Chain A Binding Site BS02

Receptor Information
>2huf Chain A (length=385) Species: 7159 (Aedes aegypti) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEYKVTPPAVLREPLVTPNKLLMGPGPSNAPQRVLDAMSRPILGHLHPET
LKIMDDIKEGVRYLFQTNNIATFCLSASGHGGMEATLCNLLEDGDVILIG
HTGHWGDRSADMATRYGADVRVVKSKVGQSLSLDEIRDALLIHKPSVLFL
TQGDSSTGVLQGLEGVGALCHQHNCLLIVDTVASLGGAPMFMDRWEIDAM
YTGSQKVLGAPPGITPVSFSHRAVERYKRRNTKVKVYYWDMSLVGDYWGC
FGRPRIYHHTISSTLLYGLREAIAMACEEGLPALIARHEDCAKRLYRGLQ
DAGFELYADPKDRLSTVTTIKVPQGVDWLKAAQYAMKTYLVEISGGLGPT
AGQVFRIGLMGQNATTERVDRVLQVFQEAVAAVKP
Ligand information
Ligand ID1BO
InChIInChI=1S/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3
InChIKeyLRHPLDYGYMQRHN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCCCO
ACDLabs 10.04OCCCC
FormulaC4 H10 O
Name1-BUTANOL;
BUTAN-1-OL
ChEMBLCHEMBL14245
DrugBankDB02145
ZINCZINC000001530354
PDB chain2huf Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2huf Crystal Structures of Aedes aegypti Alanine Glyoxylate Aminotransferase.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		H45 Y257
Binding residue
(residue number reindexed from 1)		H45 Y257
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2huf, PDBe:2huf, PDBj:2huf
PDBsum2huf
PubMed16990263
UniProtQ3LSM4|AGT_AEDAE Alanine--glyoxylate aminotransferase (Gene Name=AGT)

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