Structure of PDB 2hhx Chain A Binding Site BS02

Receptor Information
>2hhx Chain A (length=574) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLR
PETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLA
AYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHL
VRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDT
KRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVL
GYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPDTKKV
HTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWLIFAA
DYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVTPNMR
RQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKRYMEN
IVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQGSAAD
IIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCRLVPEVM
EQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
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PDB2hhx The structural basis for the mutagenicity of O6-methyl-guanine lesions.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		N527 N529 S530 S585 T586 T611 Q612 T613 R615 S617 S618 T619 N622 F710 G711 Y714 G720 N724 R771 F786 R789 Q797
Binding residue
(residue number reindexed from 1)		N230 N232 S233 S283 T284 T309 Q310 T311 R313 S315 S316 T317 N320 F408 G409 Y412 G418 N422 R469 F484 R487 Q495
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2hhx, PDBe:2hhx, PDBj:2hhx
PDBsum2hhx
PubMed17179038
UniProtQ5KWC1

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