Structure of PDB 2hhq Chain A Binding Site BS02

Receptor Information

>2hhq Chain A (length=580) Species: 1422 (Geobacillus stearothermophilus)

KKMAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFL
RPETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLL
AAYLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEH
LVRKAAAIWELERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVD
TKRLEQMGKELAEQLGTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPV
LKKTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVR
PDTKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESD
WLIFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDE
VTPNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGV
KRYMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPI
QGSAADIIKKAMIDLNARLKEERLQAHLLLQVHDELILEAPKEEMERLCR
LVPEVMEQAVTLRVPLKVDYHYGSTWYDAK

Ligand information

>2hhq Chain C (length=15)

gcctgactcgtatga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2hhq The structural basis for the mutagenicity of O6-methyl-guanine lesions.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): N527 N529 S530 S585 T586 L610 T611 Q612 T613 S617 S618 T619 N622 G711 Y714 G715 I716 S717 G720 L721 N724 R771 F786 R789 M790 Q797
• Binding residue (residue number reindexed from 1): N231 N233 S234 S289 T290 L314 T315 Q316 T317 S321 S322 T323 N326 G415 Y418 G419 I420 S421 G424 L425 N428 R475 F490 R493 M494 Q501

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0008408 3'-5' exonuclease activity

Biological Process

• GO:0006139 nucleobase-containing compound metabolic process
• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication

External links

• PDB: RCSB:2hhq, PDBe:2hhq, PDBj:2hhq
• PDBsum: 2hhq
• PubMed: 17179038
• UniProt: Q45458