Structure of PDB 2hcs Chain A Binding Site BS02

Receptor Information
>2hcs Chain A (length=487) Species: 11077 (Kunjin virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVNGVVRLLSKPWDTIDTKAPEPPEGVKYVLNETTNWLWAFLAREKRPRM
CSREEFIRKVNSNAAQWRSAREAVEDPKFWEMVDEEREAHLRGECHTCSR
AIWFMWLGARFLEFEALGFLNEDHWLGRKNSGGGVEGLGLQKLGYILREV
GTRPGGRIYADDTAGWDTRITRADLENEAKVLELLDGEHRRLARAIIELT
YRGSGQVVTYALNTFTNLAVQLVRMMEGEGVIGPDDVEKLTKGKGPKVRT
WLSENGEERLSRMAVSGDDCVVKPLDDRFATSLHFLNAMSKVRKDIQEWK
PSTGWYDWQQVPFCSNHFTELIMKDGRTLVTPCRGQDELVGRARISPNVR
DTACLAKSYAQMWLLLYFHRRDLRLMANAICSAVPVNWVPTGRTTWSIHA
GGEWMTTEDMLEVWNRVWIEENEWMEDKTPVEKWSDVPYSGKREDIWCGS
LIGTRARATWAENIQVAINQVRSIIGDEKYVDYMSSL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2hcs Chain A Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2hcs Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H717 C733 C852
Binding residue
(residue number reindexed from 1)		H317 C333 C448
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2hcs, PDBe:2hcs, PDBj:2hcs
PDBsum2hcs
PubMed17287213
UniProtP14335|POLG_KUNJM Genome polyprotein

[Back to BioLiP]