Structure of PDB 2gii Chain A Binding Site BS02

Receptor Information
>2gii Chain A (length=238) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKPIYQDINSILIGQKEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMK
NPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADIL
LVKDQFYELLDVKTRNISKSAFAPNIISAYKLAQTCAKMIDNKEFDLFDI
NYLEVDWELLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFN
GTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2gii Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E35 Q109 A137 F138 P140 N141 S144 A205 Q207
Binding residue
(residue number reindexed from 1)		E19 Q93 A121 F122 P124 N125 S128 A185 Q187
Binding affinityPDBbind-CN: Kd=0.42nM
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:2gii, PDBe:2gii, PDBj:2gii
PDBsum2gii
PubMed16675462
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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