Structure of PDB 2fyf Chain A Binding Site BS02

Receptor Information
>2fyf Chain A (length=368) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNL
VGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGE
FSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTG
VAVAVRRPEGSDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGL
WLAIMSPAALSRIEAIAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATL
ALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLR
SQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVE
PDDVSALTECVDWVVERL
Ligand information
Ligand IDPC4
InChIInChI=1S/4ClH.Pt/h4*1H;/q;;;;+2/p-4
InChIKeySVZRVTAEYVVVPM-UHFFFAOYSA-J
SMILES
SoftwareSMILES
CACTVS 3.341Cl[Pt--](Cl)(Cl)Cl
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		Cl[Pt-2](Cl)(Cl)Cl
FormulaCl4 Pt
NameTETRACHLOROPLATINATE(II)
ChEMBL
DrugBank
ZINC
PDB chain2fyf Chain A Residue 1378 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fyf Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H8 L9 I329 A332
Binding residue
(residue number reindexed from 1)		H1 L2 I321 A324
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) F108 D176 K200
Catalytic site (residue number reindexed from 1) F101 D168 K192
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0008615 pyridoxine biosynthetic process
GO:0009058 biosynthetic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fyf, PDBe:2fyf, PDBj:2fyf
PDBsum2fyf
PubMed22525753
UniProtP9WQ73|SERC_MYCTU Phosphoserine aminotransferase (Gene Name=serC)

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