Structure of PDB 2fvy Chain A Binding Site BS02

Receptor Information

>2fvy Chain A (length=305) Species: 562 (Escherichia coli)

DTRIGVTIYKYDDNFMSVVRKAIEQDAKAAPDVQLLMNDSQNDQSKQNDQ
IDVLLAKGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKALDS
YDKAYYVGTDSKESGIIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPG
HPDAEARTTYVIKELNDKGIKTEQLQLDTAMWDTAQAKDKMDAWLSGPNA
NKIEVVIANNDAMAMGAVEALKAHNKSSIPVFGVDALPEALALVKSGALA
GTVLNDANNQAKATFDLAKNLADGKGAADGTNWKIDNKVVRVPYVGVDKD
NLAEF

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2fvy Chain A Residue 311

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fvy Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.
• Resolution: 0.92 Å
• Binding residue (original residue number in PDB): D134 N136 D138 Q140 Q142 E205
• Binding residue (residue number reindexed from 1): D133 N135 D137 Q139 Q141 E204
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0030246 carbohydrate binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006935 chemotaxis
• GO:0015757 galactose transmembrane transport
• GO:0015765 methylgalactoside transport

Cellular Component

• GO:0016020 membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

External links

• PDB: RCSB:2fvy, PDBe:2fvy, PDBj:2fvy
• PDBsum: 2fvy
• PubMed: 17473016
• UniProt: P0AEE5|MGLB_ECOLI D-galactose/methyl-galactoside binding periplasmic protein MglB (Gene Name=mglB)