Structure of PDB 2fuc Chain A Binding Site BS02

Receptor Information

>2fuc Chain A (length=245) Species: 9606 (Homo sapiens)

ERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIAE
QLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINF
CLSYMALLRLPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEK
IREKFVEALKTEFAGKGLRFSRGGMISFDVFPEGWDKRYCLDSLDQDSFD
TIHFFGNETSPGGNDFEIFADPRTVGHSVVSPQDTVQRCREIFFP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2fuc Chain A Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2fuc The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): F230 D232 T235
• Binding residue (residue number reindexed from 1): F219 D221 T224
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.4.2.8: phosphomannomutase.

Gene Ontology

Molecular Function

• GO:0004615 phosphomannomutase activity
• GO:0005515 protein binding
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006013 mannose metabolic process
• GO:0006487 protein N-linked glycosylation
• GO:0009298 GDP-mannose biosynthetic process
• GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0043025 neuronal cell body

External links

• PDB: RCSB:2fuc, PDBe:2fuc, PDBj:2fuc
• PDBsum: 2fuc
• PubMed: 16540464
• UniProt: Q92871|PMM1_HUMAN Phosphomannomutase 1 (Gene Name=PMM1)