Structure of PDB 2fo1 Chain A Binding Site BS02

Receptor Information
>2fo1 Chain A (length=439) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTLKASAIHEQQATELVAYIGIGSDTSERQQLDF
STGKVRHPNIYDYCAAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQ
RIKVISKPSKKDCKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHAS
STKWGAFTIHLFDDEDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKV
DKQQVILDASCSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAIN
EHRHQINDGAAWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHG
EASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQT
HWMFTNRTTGDVEVPISLVRDDGVVYSSGLTFSYKSLER
Ligand information
Receptor-Ligand Complex Structure
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PDB2fo1 Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Resolution3.12 Å
Binding residue
(original residue number in PDB)		K227 Y229 S367 K368 S370
Binding residue
(residue number reindexed from 1)		K33 Y35 S156 K157 S159
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fo1, PDBe:2fo1, PDBj:2fo1
PDBsum2fo1
PubMed16530045
UniProtV6CLJ5|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)

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