Structure of PDB 2fge Chain A Binding Site BS02

Receptor Information
>2fge Chain A (length=979) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEAEKLGFEKVSEEFISECKSKAILFKHKKTGCEVMSVSNEDENKVFGVV
FRTPPKDSTGIPHILQHSVLCGSRKYPVKEPFVELLKGSLHTFLNAFTYP
DRTCYPVASTNTKDFYNLVDVYLDAVFFPKCVDDAHTFQQEGWHYELNDP
SEDISYKGVVFNEMKGVYSQPDNILGRIAQQALSPENTYGVDSGGDPKDI
PNLTFEEFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFEASPS
PNSSKIKFQKLFSEPVRLVEKYPAGRDGDLKKKHMLCVNWLLSEKPLDLQ
TQLALGFLDHLMLGTPASPLRKILLESGLGEALVSSGLSDELLQPQFGIG
LKGVSEENVQKVEELIMDTLKKLAEEGFDNDAVEASMNTIEFSLRENNTG
SFPRGLSLMLQSISKWIYDMDPFEPLKYTEPLKALKTRIAEEGSKAVFSP
LIEKLILNNSHRVTIEMQPDPEKATQEEVEEKNILEKVKAAMTEEDLAEL
ARATEELKLKQETPDPPEALRCVPSLNLGDIPKEPTYVPTEVGDINGVKV
LRHDLFTNDIIYTEVVFDIGSLKHELLPLVPLFCQSLLEMGTKDLTFVQL
NQLIGRKTGGISVYPLTSSVRGKDEPCSKIIVRGKSMAGRADDLFNLMNC
LLQEVQFTDQQRFKQFVSQSRARMENRLRGSGHGIAAARMDAMLNIAGWM
SEQMGGLSYLEFLHTLEKKVDEDWEGISSSLEEIRRSLLARNGCIVNMTA
DGKSLTNVEKSVAKFLDLLPENPSGGLVTWDGRLPLRNEAIVIPTQVNYV
GKAGNIYSTGYELDGSAYVISKHISNTWLWDRVRVSGGAYGGFCDFDSHS
GVFSYLSYRDPNLLKTLDIYDGTGDFLRGLDVDQETLTKAIIGTIGDVDS
YQLPDAKGYSSLLRHLLGVTDEERQRKREEILTTSLKDFKDFAQAIDVVR
DKGVAVAVASAEDIDAANNERSNFFEVKK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2fge Chain A Residue 996 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2fge The closed structure of presequence protease PreP forms a unique 10 000 A(3) chamber for proteolysis
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H77 H81 E177
Binding residue
(residue number reindexed from 1)		H63 H67 E163
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0009941 chloroplast envelope
GO:0048046 apoplast

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2fge, PDBe:2fge, PDBj:2fge
PDBsum2fge
PubMed16601675
UniProtQ9LJL3|PREP1_ARATH Presequence protease 1, chloroplastic/mitochondrial (Gene Name=PREP1)

[Back to BioLiP]