Structure of PDB 2f9p Chain A Binding Site BS02
Receptor Information
>2f9p Chain A (length=243) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDV
KDLATLRVQLREQHLYYQDQLLPVSRIIVHPQFYIIQTGADIALLELEEP
VNISSRVHTVMLPPASETFPPGMPCWVTGWGDVDNDEPLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIIRDDMLCAGNSQRDSCKGDSGGPLVC
KVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK
Ligand information
Ligand ID
BU3
InChI
InChI=1S/C4H10O2/c1-3(5)4(2)6/h3-6H,1-2H3/t3-,4-/m1/s1
InChIKey
OWBTYPJTUOEWEK-QWWZWVQMSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
C[C@H]([C@@H](C)O)O
CACTVS 3.341
C[C@@H](O)[C@@H](C)O
ACDLabs 10.04
OC(C)C(O)C
OpenEye OEToolkits 1.5.0
CC(C(C)O)O
CACTVS 3.341
C[CH](O)[CH](C)O
Formula
C4 H10 O2
Name
(R,R)-2,3-BUTANEDIOL
ChEMBL
DrugBank
ZINC
ZINC000000901616
PDB chain
2f9p Chain A Residue 1250 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
2f9p
X-ray Structures of Free and Leupeptin-complexed Human alpha I-Tryptase Mutants: Indication for an alpha to beta-Tryptase Transition
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
Q221A P222 R224
Binding residue
(residue number reindexed from 1)
Q220 P221 R223
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)
H44 D91 K191 G192 D193 S194 G195
Enzyme Commision number
3.4.21.59
: tryptase.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008236
serine-type peptidase activity
GO:0042802
identical protein binding
Biological Process
GO:0006508
proteolysis
GO:0006952
defense response
GO:0022617
extracellular matrix disassembly
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0062023
collagen-containing extracellular matrix
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:2f9p
,
PDBe:2f9p
,
PDBj:2f9p
PDBsum
2f9p
PubMed
16414069
UniProt
Q15661
|TRYB1_HUMAN Tryptase alpha/beta-1 (Gene Name=TPSAB1)
[
Back to BioLiP
]