Structure of PDB 2f6d Chain A Binding Site BS02

Receptor Information
>2f6d Chain A (length=492) Species: 4944 (Saccharomycopsis fibuligera) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AYPSFEAYSNYKVDRTDLETFLDKQKEVSLYYLLQNIAYPEGQFNNGVPG
TVIASPSTSNPDYYYQWTRDSAITFLTVLSELEDNNFNTTLAKAVEYYIN
TSYNLQRTSNPSGSFDDENHKGLGEPKFNTDGSAYTGAWGRPQNDGPALR
AYAISRYLNDVNSLNEGKLVLTDSGDINFSSTEDIYKNIIKPDLEYVIGY
WDSTGFDLWEENQGRHFFTSLVQQKALAYAVDIAKSFDDGDFANTLSSTA
STLESYLSGSDGGFVNTDVNHIVENPDLLQQNSRQGLDSATYIGPLLTHD
IGESSSTPFDVDNEYVLQSYYLLLEDNKDRYSVNSAYSAGAAIGRYPEDV
YNGDGSSEGNPWFLATAYAAQVPYKLAYDAKSASNDITINKINYDFFNKY
IVDLSTINSAYQSSDSVTIKSGSDEFNTVADNLVTFGDSFLQVILDHIND
DGSLNEQLNRYTGYSTGAYSLTWSSGALLEAIRLRNKVKALA
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain2f6d Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2f6d Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		W139 G140 E210
Binding residue
(residue number reindexed from 1)		W139 G140 E210
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) W139 D207 E210 E211 E456
Catalytic site (residue number reindexed from 1) W139 D207 E210 E211 E456
Enzyme Commision number 3.2.1.3: glucan 1,4-alpha-glucosidase.
Gene Ontology
Molecular Function
GO:0004339 glucan 1,4-alpha-glucosidase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0005976 polysaccharide metabolic process
Cellular Component
GO:0000324 fungal-type vacuole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2f6d, PDBe:2f6d, PDBj:2f6d
PDBsum2f6d
PubMed16649993
UniProtP08017|AMYG_SACFI Glucoamylase GLU1 (Gene Name=GLU1)

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