Structure of PDB 2dxr Chain A Binding Site BS02

Receptor Information

>2dxr Chain A (length=341) Species: 9913 (Bos taurus)

YTRVVWCAVGPEEQKKCQQWSQQSGQNVTCATASTTDDCIVLVLKGEADA
LNLDGGYIYTAGKCGLVPVLAENRKSSKHSSLDCVLRPTEGYLAVAVVKK
ANEGLTWNSLKDKKSCHTAVDRTAGWNIPMGLIVNQTGSCAFDEFFSQSC
APGADPKSRLCALCAGDDQGLDKCVPNSKEKYYGYTGAFRCLAEDVGDVA
FVKNDTVWENTNGESTADWAKNLKREDFRLLCLDGTRKPVTEAQSCHLAV
APNHAVVSRSDRAAHVEQVLLHQQALFGKNGKNCPDKFCLFKSETKNLLF
NDNTECLAKLGGRPTYEEYLGTEYVTAIANLKKCSLEACAF

Ligand information

• Ligand ID: SOR
• InChI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
• InChIKey: FBPFZTCFMRRESA-JGWLITMVSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
  CACTVS 3.341: OC[CH](O)[CH](O)[CH](O)[CH](O)CO
  ACDLabs 10.04: OC(C(O)CO)C(O)C(O)CO
  CACTVS 3.341: OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
  OpenEye OEToolkits 1.5.0: C(C(C(C(C(CO)O)O)O)O)O
• Formula: C6 H14 O6
• Name: sorbitol;
  D-sorbitol;
  D-glucitol
• ChEMBL: CHEMBL1682
• DrugBank: DB01638
• ZINC: ZINC000018279893
• PDB chain: 2dxr Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2dxr Crystal structure of the complex formed between C-terminal half of bovine lactoferrin and sorbitol at 2.85 A resolution
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): T430 Y660
• Binding residue (residue number reindexed from 1): T89 Y319
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.21.-

Gene Ontology

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:2dxr, PDBe:2dxr, PDBj:2dxr
• PDBsum: 2dxr
• UniProt: P24627|TRFL_BOVIN Lactotransferrin (Gene Name=LTF)