Structure of PDB 2du3 Chain A Binding Site BS02

Receptor Information
>2du3 Chain A (length=534) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFDPQKYRELAEKDFEAAWKAGKEILAERSPNELYPRVGFSFGKEHPLF
ATIQRLREAYLSIGFSEVVNPLIVEDVHVKKQFGREALAVLDRCFYLATL
PKPNVGISAEKIRQIEAITKREVDSKPLQEIFHRYKKGEIDGDDLSYLIA
EVLDVDDITAVKILDEVFPEFKELKPISSTLTLRSHMTTGWFITLSHIAD
KLPLPIKLFSIDRCFRREQGEDATRLYTYFSASCVLVDEELSVDDGKAVA
EALLRQFGFENFRFRKDEKRSKYYIPDTQTEVFAFHPKLVGSSTKYSDGW
IEIATFGIYSPTALAEYDIPYPVMNLGLGVERLAMILYGYDDVRKMVYPQ
IHGEIKLSDLDIAREIKVKEVPQTAVGLKIAQSIVETAEKHASEPSPCSF
LAFEGEMMGRNVRVYVVEEEENTKLCGPAYANEVVVYKGDIYGIPKTKKW
RSFFEEGVPTGIRYIDGFAYYAARKVEEAAMREQEEVKVKARIVENLSDI
NLYIHENVRRYILWKKGKIDVRGPLFVTVKAEIE
Ligand information
Ligand IDSEP
InChIInChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
InChIKeyBZQFBWGGLXLEPQ-REOHCLBHSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC(C(=O)O)N
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)OP(=O)(O)O
CACTVS 3.341N[CH](CO[P](O)(O)=O)C(O)=O
CACTVS 3.341N[C@@H](CO[P](O)(O)=O)C(O)=O
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)OP(=O)(O)O
FormulaC3 H8 N O6 P
NamePHOSPHOSERINE;
PHOSPHONOSERINE
ChEMBLCHEMBL284377
DrugBankDB04522
ZINCZINC000003869280
PDB chain2du3 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2du3 Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H186 M187 T188 S231 S233 Y273 Y274 T305 N325 G327
Binding residue
(residue number reindexed from 1)		H186 M187 T188 S231 S233 Y273 Y274 T305 N325 G327
Annotation score5
Enzymatic activity
Enzyme Commision number 6.1.1.27: O-phosphoserine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042802 identical protein binding
GO:0043816 phosphoserine-tRNA(Cys) ligase activity
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2du3, PDBe:2du3, PDBj:2du3
PDBsum2du3
PubMed17351629
UniProtO30126|SEPS_ARCFU O-phosphoserine--tRNA(Cys) ligase (Gene Name=sepS)

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