Structure of PDB 2dq5 Chain A Binding Site BS02

Receptor Information
>2dq5 Chain A (length=47) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2dq5 Chain A Residue 1187 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2dq5 Solution Structure of the MID1 B-box2 CHC(D/C)C(2)H(2) Zinc-binding Domain: Insights into an Evolutionarily Conserved RING Fold
ResolutionN/A
Binding residue
(original residue number in PDB)		C187 D190 H204 H207
Binding residue
(residue number reindexed from 1)		C20 D23 H37 H40
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:2dq5, PDBe:2dq5, PDBj:2dq5
PDBsum2dq5
PubMed17428496
UniProtO15344|TRI18_HUMAN E3 ubiquitin-protein ligase Midline-1 (Gene Name=MID1)

[Back to BioLiP]