Structure of PDB 2dfi Chain A Binding Site BS02

Receptor Information
>2dfi Chain A (length=301) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDTEKLMKAGEIAKKVREKAIKLARPGMLLLELAESIEKMIMELGGKPAF
PVNLSINEIAAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRV
GMEEDELMEAAKEALNAAISVARAGVEIKELGKAIENEIRKRGFKPIVNL
SGHKIERYKLHAGISIPNIYRPHDNYVLKEGDVFAIEPFATIGAGQVIEV
PPTLIYMYVRDVPVRVAQARFLLAKIKREYGTLPFAYRWLQNDMPEGQLK
LALKTLEKAGAIYGYPVLKEIRNGIVAQFEHTIIVEKDSVIVTQDMINKS
T
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain2dfi Chain A Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2dfi Conformational contagion in a protein: Structural properties of a chameleon sequence
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D93 H153 E187 E280
Binding residue
(residue number reindexed from 1)		D93 H153 E187 E280
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) D82 D93 H153 H161 E187 E280
Catalytic site (residue number reindexed from 1) D82 D93 H153 H161 E187 E280
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2dfi, PDBe:2dfi, PDBj:2dfi
PDBsum2dfi
PubMed17510955
UniProtP56218|MAP2_PYRFU Methionine aminopeptidase (Gene Name=map)

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