Structure of PDB 2czi Chain A Binding Site BS02

Receptor Information
>2czi Chain A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PWEECFQAAVQLALRAGQIIRKALTEETKTSAADLVTETDHLVEDLIISE
LRERFPSHRFIAEEAKCVLTHSPTWIIDPIDGTCNFVHRFPTVAVSIGFA
VRQELEFGVIYHCTEERLYTGRRGRGAFCNGQRLRVSGETDLSKALVLTE
IGPKRDPATLKLFLSNMERLLHAKAHGVRVIGSSTLALCHLASGAADAYY
QFGLHCWDLAAATVIIREAGGIVIDTSGGPLDLMACRVVAASTREMAMLI
AQALQTINY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2czi Chain A Residue 290 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2czi Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D101 D104 D231
Binding residue
(residue number reindexed from 1)		D78 D81 D208
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E81 D101 I103 D104 T106 D231
Catalytic site (residue number reindexed from 1) E63 D78 I80 D81 T83 D208
Enzyme Commision number 3.1.3.25: inositol-phosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008934 inositol monophosphate 1-phosphatase activity
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052832 inositol monophosphate 3-phosphatase activity
GO:0052833 inositol monophosphate 4-phosphatase activity
GO:0052834 inositol monophosphate phosphatase activity
Biological Process
GO:0006020 inositol metabolic process
GO:0006021 inositol biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0007165 signal transduction
GO:0010226 response to lithium ion
GO:0046854 phosphatidylinositol phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2czi, PDBe:2czi, PDBj:2czi
PDBsum2czi
PubMed17340635
UniProtO14732|IMPA2_HUMAN Inositol monophosphatase 2 (Gene Name=IMPA2)

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