Structure of PDB 2ch2 Chain A Binding Site BS02

Receptor Information
>2ch2 Chain A (length=387) Species: 7165 (Anopheles gambiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTPPPASLRNPLIIPEKIMMGPGPSNCSKRVLTAMTNTVLSNFHAELFRT
MDEVKDGLRYIFQTENRATMCVSGSAHAGMEAMLSNLLEEGDRVLIAVNG
IWAERAVEMSERYGADVRTIEGPPDRPFSLETLARAIELHQPKCLFLTHG
DSSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGVPFYMDKWEIDAVYTG
AQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYWGCYDE
PKRYHHTVASNLIFALREALAQIAEEGLENQIKRRIECAQILYEGLGKMG
LDIFVKDPRHRLPTVTGIMIPKGVDWWKVSQYAMNNFSLEVQGGLGPTFG
KAWRVGIMGECSTVQKIQFYLYGFKESLKATHPDYIF
Ligand information
Ligand IDKY1
InChIInChI=1S/C10H11NO3/c11-8-4-2-1-3-7(8)9(12)5-6-10(13)14/h1-4H,5-6,11H2,(H,13,14)
InChIKeyBIASMBPERGWEBX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)CCC(=O)O)N
CACTVS 3.341Nc1ccccc1C(=O)CCC(O)=O
ACDLabs 10.04O=C(c1ccccc1N)CCC(=O)O
FormulaC10 H11 N O3
Name4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID
ChEMBLCHEMBL1233898
DrugBankDB08060
ZINCZINC000013356580
PDB chain2ch2 Chain D Residue 1390 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2ch2 Crystal Structure of the Anopheles Gambiae 3-Hydroxykynurenine Transaminase
Resolution2.7 Å
Binding residue
(original residue number in PDB)		G25 S154 Q344 L347 R356
Binding residue
(residue number reindexed from 1)		G23 S152 Q342 L345 R354
Annotation score2
Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
2.6.1.63: kynurenine--glyoxylate transaminase.
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0047315 kynurenine-glyoxylate transaminase activity
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005777 peroxisome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2ch2, PDBe:2ch2, PDBj:2ch2
PDBsum2ch2
PubMed16585514
UniProtQ7PRG3|HKT_ANOGA 3-hydroxykynurenine transaminase (Gene Name=HKT)

[Back to BioLiP]