Structure of PDB 2c78 Chain A Binding Site BS02

Receptor Information

>2c78 Chain A (length=397) Species: 300852 (Thermus thermophilus HB8)

KPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDIDKAPEERA
RGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDGAILVVSA
ADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVEMEVRDLL
NQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWELLDAIDE
YIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGDEVEIVGL
APETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERGQVLAKPG
SITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTGVVQLPPG
VEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVTKILE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2c78 Chain A Residue 1407

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2c78 Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
• Resolution: 1.4 Å
• Binding residue (original residue number in PDB): T25 T62
• Binding residue (residue number reindexed from 1): T17 T54
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D21 K24 T25 T62 H85
• Catalytic site (residue number reindexed from 1): D13 K16 T17 T54 H77
• Enzyme Commision number: 3.1.5.1: dGTPase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2c78, PDBe:2c78, PDBj:2c78
• PDBsum: 2c78
• PubMed: 16734421
• UniProt: Q5SHN6|EFTU1_THET8 Elongation factor Tu-A (Gene Name=tufA)