Structure of PDB 2b9s Chain A Binding Site BS02

Receptor Information
>2b9s Chain A (length=426) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKM
TPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPIRRLELC
DFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQV
ANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHK
WAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKL
KDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADT
VGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTR
RKSPGMDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKP
WSTADKLAYFNKANTEVAILCNHQKS
Ligand information
Receptor-Ligand Complex Structure
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PDB2b9s The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA.
Resolution2.27 Å
Binding residue
(original residue number in PDB)		H93 R190 R314 K352 D353 I355 H453 Q454 S456
Binding residue
(residue number reindexed from 1)		H67 R164 R288 K326 D327 I329 H423 Q424 S426
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2b9s, PDBe:2b9s, PDBj:2b9s
PDBsum2b9s
PubMed16487540
UniProtQ9GPZ9

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