Structure of PDB 2al5 Chain A Binding Site BS02

Receptor Information
>2al5 Chain A (length=260) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK
LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDF
SKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKI
AVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQ
RKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKN
KWWYDKGECG
Ligand information
Ligand ID4MP
InChIInChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3
InChIKeyZXNRTKGTQJPIJK-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C2N(C(=O)c1ccc(OC)cc1)CCC2
CACTVS 3.341
OpenEye OEToolkits 1.5.0		COc1ccc(cc1)C(=O)N2CCCC2=O
FormulaC12 H13 N O3
Name1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE;
ANIRACETAM;
1-P-ANISOYL-2-PYRROLIDINONE
ChEMBLCHEMBL36994
DrugBankDB04599
ZINCZINC000000015951
PDB chain2al5 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2al5 Mechanism of positive allosteric modulators acting on AMPA receptors.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		P105 S108 S217 K218 N242
Binding residue
(residue number reindexed from 1)		P103 S106 S215 K216 N240
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2al5, PDBe:2al5, PDBj:2al5
PDBsum2al5
PubMed16192394
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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