Structure of PDB 2ahi Chain A Binding Site BS02

Receptor Information

>2ahi Chain A (length=198) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQ
LWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHL
IRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMG
GMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKK

Ligand information

>2ahi Chain F (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggacatgtccg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ahi Structural Basis of DNA Recognition by p53 Tetramers
Resolution	1.85 Å
Binding residue (original residue number in PDB)	S241 R248 R273 C275 A276 R280
Binding residue (residue number reindexed from 1)	S147 R154 R179 C181 A182 R186
Binding affinity	PDBbind-CN: Kd=20nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:2ahi, PDBe:2ahi, PDBj:2ahi
PDBsum	2ahi
PubMed	16793544
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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