Structure of PDB 2a4g Chain A Binding Site BS02

Receptor Information
>2a4g Chain A (length=181) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS
Ligand information
>2a4g Chain D (length=16) Species: 31647 (Hepatitis C virus subtype 1b) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GSVVIVGRIVLSGKPA
Receptor-Ligand Complex Structure
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PDB2a4g Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		T4 A5 Y6 A7 Q8
Binding residue
(residue number reindexed from 1)		T4 A5 Y6 A7 Q8
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H57 D81 G137 S139
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:2a4g, PDBe:2a4g, PDBj:2a4g
PDBsum2a4g
PubMed16087332
UniProtP26664|POLG_HCV1 Genome polyprotein

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