Structure of PDB 2a06 Chain A Binding Site BS02

Receptor Information

>2a06 Chain A (length=442) Species: 9913 (Bos taurus)

TATYAQALQSVPETQVSQLDNGLRVASEQSSQPTCTVGVWIDAGSRYESE
KNNGAGYFVEHLAFKGTKNRPGNALEKEVESMGAHLNAYSTREHTAYYIK
ALSKDLPKAVELLADIVQNCSLEDSQIEKERDVILQELQENDTSMRDVVF
NYLHATAFQGTPLAQSVEGPSENVRKLSRADLTEYLSRHYKAPRMVLAAA
GGLEHRQLLDLAQKHFSGLSGTYDEDAVPTLSPCRFTGSQICHREDGLPL
AHVAIAVEGPGWAHPDNVALQVANAIIGHYDCTYGGGAHLSSPLASIAAT
NKLCQSFQTFNICYADTGLLGAHFVCDHMSIDDMMFVLQGQWMRLCTSAT
ESEVLRGKNLLRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIA
EVDARVVREVCSKYFYDQCPAVAGFGPIEQLPDYNRIRSGMF

Ligand information

• Ligand ID: AZI
• InChI: InChI=1S/N3/c1-3-2/q-1
• InChIKey: IVRMZWNICZWHMI-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [N-]=[N+]=[N-]
• Formula: N3
• Name: AZIDE ION
• ChEMBL: CHEMBL79455
• PDB chain: 2a06 Chain A Residue 4002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2a06 Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc(1) Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): L62 K65 L122 E123 Q126
• Binding residue (residue number reindexed from 1): L62 K65 L122 E123 Q126
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Y57 E60 H61 E130 E137
• Catalytic site (residue number reindexed from 1): Y57 E60 H61 E130 E137
• Enzyme Commision number: 1.10.2.2: Transferred entry: 7.1.1.8.

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:2a06, PDBe:2a06, PDBj:2a06
• PDBsum: 2a06
• PubMed: 16024040
• UniProt: P31800|QCR1_BOVIN Cytochrome b-c1 complex subunit 1, mitochondrial (Gene Name=UQCRC1)