Structure of PDB 1zyq Chain A Binding Site BS02

Receptor Information
>1zyq Chain A (length=680) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFGAYLDALEAEV
ARGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHS
NLKDTDMGLLRSGKLPGALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVD
GMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSELLRK
LTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKTPKVGGLDTREYVAGA
PYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLEGVRV
DDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGSVNPNG
AVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGITGKPWVQAGI
DASGLELRCLAHFMARFDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTF
IYGFLYGAGDEAIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLV
ESSQWVAGEQQVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICKL
WIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQ
EAMRWVGDHWNFRCLLDTEGKMGPNWAICH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zyq A lysine residue in the fingers subdomain of t7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		S337 S338 H341 K404 A425 V426 H432 A433 Q439 Y526 G527 Y530 A532 G533 A536 R604 H607 Q615
Binding residue
(residue number reindexed from 1)		S313 S314 H317 K380 A401 V402 H408 A409 Q415 Y502 G503 Y506 A508 G509 A512 R580 H583 Q591
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006302 double-strand break repair
GO:0039693 viral DNA genome replication
GO:0090592 DNA synthesis involved in DNA replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zyq, PDBe:1zyq, PDBj:1zyq
PDBsum1zyq
PubMed16271888
UniProtP00581|DPOL_BPT7 DNA-directed DNA polymerase (Gene Name=5)

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