Structure of PDB 1zet Chain A Binding Site BS02

Receptor Information
>1zet Chain A (length=388) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zet DNA polymerases: Hoogsteen base-pairing in DNA replication?
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L123 G124 E127 K207 G241 K245 R343 R357 E358 S359 R360 Q361 C362 P363 L390 M394
Binding residue
(residue number reindexed from 1)		L97 G98 E101 K181 G215 K219 R317 R331 E332 S333 R334 Q335 C336 P337 L364 M368
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1zet, PDBe:1zet, PDBj:1zet
PDBsum1zet
PubMed16163299
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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