Structure of PDB 1z26 Chain A Binding Site BS02

Receptor Information
>1z26 Chain A (length=716) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMKAIVVINLVKINKKIIPDKIYVYRLYSIYRLAYENVGIVIDPENLIIA
TTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENGIGEYELSKLLR
KFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQSMKTLWELVNK
DPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKKPKLDHNQEIVK
YWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFASKNYKIYLLPQ
LVVPTYNAEQLAKEILEYTKLMPEERKELLENILAEVDSDIIDKSLSEIE
VEKIAQELENKIRVRDDKGNSVPISQLLWTNYSRKYPVILPYEVPEKFRK
IREIPMFIILDSGLLADIQNFATNEFRELVKSMYYSLAKKYKEKVITEDL
NSDKGIIEVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNV
ISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFN
YDYIIGIDVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDM
NEFFKEMVDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEV
VTMDVIKNHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKR
IIKNGKVEKQSITRQDVLDIFILTRLNYGSIRLPAPVHYAHKFANAIRNE
WKIKEEFLAEGFLYFV
Ligand information
Ligand IDWO4
InChIInChI=1S/4O.W/q;;2*-1;
InChIKeyPBYZMCDFOULPGH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-][W](=O)(=O)[O-]
ACDLabs 10.04
CACTVS 3.341		[O-][W]([O-])(=O)=O
FormulaO4 W
NameTUNGSTATE(VI)ION
ChEMBL
DrugBank
ZINC
PDB chain1z26 Chain A Residue 772 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1z26 Purified Argonaute2 and an siRNA form recombinant human RISC.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q326 E329 K668
Binding residue
(residue number reindexed from 1)		Q306 E309 K618
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:1z26, PDBe:1z26, PDBj:1z26
PDBsum1z26
PubMed15800637
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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