Structure of PDB 1xm8 Chain A Binding Site BS02

Receptor Information

>1xm8 Chain A (length=254) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MQIELVPCLKDNYAYILHDEDTGTVGVVDPSEAEPIIDSLKRSGRNLTYI
LNTHHHYDHTGGNLELKDRYGAKVIGSAMDKDRIPGIDMALKDGDKWMFA
GHEVHVMDTPGHTKGHISLYFPGSRAIFTGDTMFSLSCGKLFEGTPKQML
ASLQKITSLPDDTSIYCGHEYTLSNSKFALSLEPNNEVLQSYAAHVAELR
SKKLPTIPTTVKMEKACNPFLRSSNTDIRRALRIPEAADEAEALGIIRKA
KDDF

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

1xm8 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1xm8 Structural studies on a mitochondrial glyoxalase II.
Resolution	1.74 Å
Binding residue (original residue number in PDB)	D58 H59 D131 H169
Binding residue (residue number reindexed from 1)	D58 H59 D131 H169
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H54 H56 D58 H59 H112 D131 H169
Catalytic site (residue number reindexed from 1)	H54 H56 D58 H59 H112 D131 H169
Enzyme Commision number	3.1.2.6: hydroxyacylglutathione hydrolase.

Gene Ontology

	Molecular Function
GO:0004416	hydroxyacylglutathione hydrolase activity

	Biological Process
GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

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Molecular Function

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Biological Process

External links

PDB	RCSB:1xm8, PDBe:1xm8, PDBj:1xm8
PDBsum	1xm8
PubMed	16227621
UniProt	Q9SID3\|GLO2N_ARATH Hydroxyacylglutathione hydrolase 2, mitochondrial (Gene Name=At2g31350)

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