Structure of PDB 1xhv Chain A Binding Site BS02

Receptor Information
>1xhv Chain A (length=254) Species: 727 (Haemophilus influenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFIKPIYQDINSILIGQKVKRPTLSGHAAGEPFEKLVYKFLKENLSDLTF
KQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENL
FEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAK
MIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAA
AMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFK
KYIL
Ligand information
Receptor-Ligand Complex Structure
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PDB1xhv Mechanistic Insights from the Structures of HincII Bound to Cognate DNA Cleaved from Addition of Mg(2+) and Mn(2+)
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E74 Y77 G92 K93 Q109
Binding residue
(residue number reindexed from 1)		E70 Y73 G88 K89 Q105
Enzymatic activity
Enzyme Commision number 3.1.21.4: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0009036 type II site-specific deoxyribonuclease activity
Biological Process
GO:0009307 DNA restriction-modification system

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Molecular Function
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Biological Process
External links
PDB RCSB:1xhv, PDBe:1xhv, PDBj:1xhv
PDBsum1xhv
PubMed15476804
UniProtP17743|T2C2_HAEIF Type II restriction enzyme HincII (Gene Name=hincIIR)

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