Structure of PDB 1x9w Chain A Binding Site BS02

Receptor Information
>1x9w Chain A (length=673) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFGAYLDALEAEV
ARGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHS
NLKDTDMGLLRSGKLPGALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVD
GMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSELLRK
LTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKTPKVGGIFCELDTREY
VAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLE
GVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGSV
NPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGITGKPWV
QAGIDASGLELRCLAHFMARFDNGEYAHEILNGDIHTKNQIAAELPTRDN
AKTFIYGFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALRESIQ
QTLVEKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICKLWIIKTEE
MLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRWVG
DHWNFRCLLDTEGKMGPNWAICH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1x9w Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		N335 S337 S338 D340 H341 Q393 G397 G402 D403 K404 A425 T431 H432 A433 F434 N436 Q439 Y530 R604 N611 Q615
Binding residue
(residue number reindexed from 1)		N315 S317 S318 D320 H321 Q373 G377 G382 D383 K384 A405 T411 H412 A413 F414 N416 Q419 Y510 R573 N580 Q584
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006302 double-strand break repair
GO:0039693 viral DNA genome replication
GO:0090592 DNA synthesis involved in DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1x9w, PDBe:1x9w, PDBj:1x9w
PDBsum1x9w
PubMed15528277
UniProtP00581|DPOL_BPT7 DNA-directed DNA polymerase (Gene Name=5)

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