Structure of PDB 1wzc Chain A Binding Site BS02

Receptor Information

>1wzc Chain A (length=234) Species: 53953 (Pyrococcus horikoshii)

MIRLIFLDIDKTLIPGYEPDPAKPIIEELKDMGFEIIFNSSKTRAEQEYY
RKELEVETPFISENGSAIFIPKGYFPYIVIELGIRVEKIREELKKLENIY
GLKYYGNSTKEEIEKFTGMPPELVPLAMEREYSETIFEWSRDGWEEVLVE
GGFKVTMGSRFYTVHGNSDKGKAAKILLDFYKRLGQIESYAVGDSYNDFP
MFEVVDKVFIVGSLKHKKAQNVSSIIDVLEVIKH

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1wzc Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1wzc Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): D8 I9 D10 S40 S41 S169
• Binding residue (residue number reindexed from 1): D8 I9 D10 S40 S41 S159
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.70: mannosyl-3-phosphoglycerate phosphatase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003824 catalytic activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding
• GO:0050531 mannosyl-3-phosphoglycerate phosphatase activity

Biological Process

• GO:0051479 mannosylglycerate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1wzc, PDBe:1wzc, PDBj:1wzc
• PDBsum: 1wzc
• PubMed: 19018103
• UniProt: O58690|MPGP_PYRHO Mannosyl-3-phosphoglycerate phosphatase (Gene Name=mngB)