Structure of PDB 1wne Chain A Binding Site BS02

Receptor Information

>1wne Chain A (length=476) Species: 244367 (Foot-and-mouth disease virus C-S8c1)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

Ligand information

>1wne Chain C (length=5)

ggccc

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1wne Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): Y336 D338 L386 K387 I411 R416 E422 K423 S426
• Binding residue (residue number reindexed from 1): Y336 D338 L386 K387 I411 R416 E422 K423 S426

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:1wne, PDBe:1wne, PDBj:1wne
• PDBsum: 1wne
• PubMed: 15294895
• UniProt: Q9QCE4