Structure of PDB 1w2z Chain A Binding Site BS02

Receptor Information
>1w2z Chain A (length=642) Species: 3888 (Pisum sativum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQHPLDPLTKEEFLAVQTIVQNKYPISNNRLAFHYIGLDDPEKDHVLRYE
THPTLVSIPRKIFVVAIINSQTHEILINLRIRSIVSDNIHNGYGFPILSV
DEQSLAIKLPLKYPPFIDSVKKRGLNLSEIVCSSFTMGWFGEEKNVRTVR
LDCFMKESTVNIYVRPITGITIVADLDLMKIVEYHDRDIEAVPTAENTEY
QVSKQSPPFGPKQHSLTSHQPQGPGFQINGHSVSWANWKFHIGFDVRAGI
VISLASIYDLEKHKSRRVLYKGYISELFVPYQDPTEEFYFKTFFDSGEFG
FGLSTVSLIPNRDCPPHAQFIDTYVHSANGTPILLKNAICVFEQYGNIMW
RHTENGIPNESIEESRTEVNLIVRTIVTVGNYDNVIDWEFKASGSIKPSI
ALSGILEIKGTNIKHKDEIKEDLHGKLVSANSIGIYHDHFYIYYLDFDID
GTHNSFEKTSLKTVRIKDGSSKRKSYWTTETQTAKTESDAKITIGLAPAE
LVVVNPNIKTAVGNEVGYRLIPAIPAHPLLTEDDYPQIRGAFTNYNVWVT
AYNRTEKWAGGLYVDHSRGDDTLAVWTKQNREIVNKDIVMWHVVGIHHVP
AQEDFPIMPLLSTSFELRPTNFFERNPVLKTLSPRDVAWPGC
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1w2z Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1w2z Using Xenon as a Probe for Dioxygen-Binding Sites in Copper Amine Oxidases.
Resolution2.24 Å
Binding residue
(original residue number in PDB)		D451 F452 D453 D592 I593
Binding residue
(residue number reindexed from 1)		D446 F447 D448 D587 I588
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y286 D300 Y387 H442 H444 H603
Catalytic site (residue number reindexed from 1) Y281 D295 Y382 H437 H439 H598
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0008131 primary methylamine oxidase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0048038 quinone binding
GO:0052595 aliphatic amine oxidase activity
GO:0052597 diamine oxidase activity
Biological Process
GO:0009308 amine metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1w2z, PDBe:1w2z, PDBj:1w2z
PDBsum1w2z
PubMed15533431
UniProtQ43077|AMO_PEA Primary amine oxidase

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