Structure of PDB 1v2x Chain A Binding Site BS02

Receptor Information
>1v2x Chain A (length=191) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRERTEARRRRIEEVLRRRQPDLTVLLENVHKPHNLSAILRTCDAVGVLE
AHAVNPTGGVPTFNETSGGSHKWVYLRVHPDLHEAFRFLKERGFTVYATA
LREDARDFREVDYTKPTAVLFGAEKWGVSEEALALADGAIKIPMLGMVQS
LNVSVAAAVILFEAQRQRLKAGLYDRPRLDPELYQKVLADW
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1v2x Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v2x Deep Knot Structure for Construction of Active Site and Cofactor Binding Site of tRNA Modification Enzyme
Resolution1.5 Å
Binding residue
(original residue number in PDB)		N29 H31 N55
Binding residue
(residue number reindexed from 1)		N29 H31 N55
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.34: tRNA (guanosine(18)-2'-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0141100 tRNA (guanine(18)-2'-O)-methyltransferase activity
Biological Process
GO:0002938 tRNA guanine ribose methylation
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1v2x, PDBe:1v2x, PDBj:1v2x
PDBsum1v2x
PubMed15062082
UniProtQ5SM16|TRMH_THET8 tRNA (guanosine(18)-2'-O)-methyltransferase (Gene Name=trmH)

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