Structure of PDB 1v2f Chain A Binding Site BS02
Receptor Information
>1v2f Chain A (length=368) Species:
274
(Thermus thermophilus) [
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MRLHPRTEAAKESIFPRMSGLAQRLGAVNLGQGFPSNPPPPFLLEAVRRA
LGRQDQYAPPAGLPALREALAEEFAVEPESVVVTSGATEALYVLLQSLVG
PGDEVVVLEPFFDVYLPDAFLAGAKARLVRLDLTPEGFRLDLSALEKALT
PRTRALLLNTPMNPTGLVFGERELEAIARLARAHDLFLISDEVYDELYYG
ERPRRLREFAPERTFTVGSAGKRLEATGYRVGWIVGPKEFMPRLAGMRQW
TSFSAPTPLQAGVAEALKLARREGFYEALREGYRRRRDLLAGGLRAMGLR
VYVPEGTYFLMAELPGWDAFRLVEEARVALIPASAFYLEDPPKDLFRFAF
CKTEEELHLALERLGRVV
Ligand information
Ligand ID
HCI
InChI
InChI=1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)
InChIKey
XMIIGOLPHOKFCH-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 12.01
O=C(O)CCc1ccccc1
OpenEye OEToolkits 1.7.6
c1ccc(cc1)CCC(=O)O
CACTVS 3.370
OC(=O)CCc1ccccc1
Formula
C9 H10 O2
Name
HYDROCINNAMIC ACID;
3PP;
3-PHENYLPROPIONIC ACID
ChEMBL
CHEMBL851
DrugBank
DB02024
ZINC
ZINC000000154564
PDB chain
1v2f Chain A Residue 520 [
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Receptor-Ligand Complex Structure
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PDB
1v2f
Crystal structures of glutamine:phenylpyruvate aminotransferase from Thermus thermophilus HB8: induced fit and substrate recognition
Resolution
2.35 Å
Binding residue
(original residue number in PDB)
F15 Q32 G33 F112 R347
Binding residue
(residue number reindexed from 1)
F15 Q32 G33 F112 R347
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
F112 A181 A183 K222
Catalytic site (residue number reindexed from 1)
F112 A181 A183 K222
Enzyme Commision number
2.6.1.15
: glutamine--pyruvate transaminase.
Gene Ontology
Molecular Function
GO:0008483
transaminase activity
GO:0016212
kynurenine-oxoglutarate transaminase activity
GO:0030170
pyridoxal phosphate binding
Biological Process
GO:0009058
biosynthetic process
Cellular Component
GO:0005737
cytoplasm
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1v2f
,
PDBe:1v2f
,
PDBj:1v2f
PDBsum
1v2f
PubMed
14761974
UniProt
Q75WK2
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