Structure of PDB 1uzr Chain A Binding Site BS02

Receptor Information

>1uzr Chain A (length=282) Species: 1773 (Mycobacterium tuberculosis)

RVSAINWNRLQDEKDAEVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQ
LTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKS
YSQIFSTLCSTAEIDDAFRWSEENRNLQRKAEIVLQSYRGDEPLKRKVAS
TLLESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHGYYIGYKFQ
RGLALVDDVTRAELKDYTYELLFELYDNEVEYTQDLYDEVGLTEDVKKFL
RYNANKALMNLGYEALFPRDETDVNPAILSAL

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 1uzr Chain A Residue 1293

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1uzr Crystal Structure of the Biologically Active Form of Class Ib Ribonucleotide Reductase Small Subunit from Mycobacterium Tuberculosis
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): E103 E163 E197 H200
• Binding residue (residue number reindexed from 1): E94 E154 E188 H191
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Y110 D196
• Catalytic site (residue number reindexed from 1): Y101 D187
• Enzyme Commision number: 1.17.4.1: ribonucleoside-diphosphate reductase.

Gene Ontology

Molecular Function

• GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0009263 deoxyribonucleotide biosynthetic process

Cellular Component

• GO:0005971 ribonucleoside-diphosphate reductase complex

External links

• PDB: RCSB:1uzr, PDBe:1uzr, PDBj:1uzr
• PDBsum: 1uzr
• PubMed: 15225619
• UniProt: P9WH71|RIR2B_MYCTU Ribonucleoside-diphosphate reductase subunit beta nrdF2 (Gene Name=nrdF2)