Structure of PDB 1ucd Chain A Binding Site BS02

Receptor Information
>1ucd Chain A (length=190) Species: 3673 (Momordica charantia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FDSFWFVQQWPPAVCSFQKSGSCPGSGLRTFTIHGLWPQQSGTSLTNCPG
SPFDITKISHLQSQLNTLWPNVLRANNQQFWSHEWTKHGTCSESTFNQAA
YFKLAVDMRNNYDIIGALRPHAAGPNGRTKSRQAIKGFLKAKFGKFPGLR
CRTDPQTKVSYLVQVVACFAQDGSTLIDCTRDTCGANFIF
Ligand information
Ligand IDURA
InChIInChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKeyISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC=CC(=O)N1
ACDLabs 10.04O=C1C=CNC(=O)N1
OpenEye OEToolkits 1.5.0C1=CNC(=O)NC1=O
FormulaC4 H4 N2 O2
NameURACIL
ChEMBLCHEMBL566
DrugBankDB03419
ZINCZINC000000895045
PDB chain1ucd Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ucd Structure of RNase MC1 from bitter gourd seeds in complex with 5'UMP
Resolution1.3 Å
Binding residue
(original residue number in PDB)		W5 Q39 S44
Binding residue
(residue number reindexed from 1)		W5 Q39 S44
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H34 W37 S44 E84 K87 H88
Catalytic site (residue number reindexed from 1) H34 W37 S44 E84 K87 H88
Enzyme Commision number 4.6.1.19: ribonuclease T2.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0016829 lyase activity
GO:0033897 ribonuclease T2 activity
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ucd, PDBe:1ucd, PDBj:1ucd
PDBsum1ucd
PubMed
UniProtP23540|RNMC1_MOMCH Ribonuclease MC (Gene Name=MC1)

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