Structure of PDB 1u22 Chain A Binding Site BS02

Receptor Information
>1u22 Chain A (length=746) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASHIVGYPRMGPKRELKFALESFWDGKSTAEDLQKVSADLRSSIWKQMSA
AGTKFIPSNTFAHYDQVLDTTAMLGAVPPRYGYTGGEIGLDVYFSMARGN
ASVPAMEMTKWFDTNYHYIVPELGPEVNFSYASHKAVNEYKEAKALGVDT
VPVLVGPVSYLLLSKAAKGVDKSFELLSLLPKILPIYKEVITELKAAGAT
WIQLDEPVLVMDLEGQKLQAFTGAYAELESTLSGLNVLVETYFADIPAEA
YKTLTSLKGVTAFGFDLVRGTKTLDLVKAGFPEGKYLFAGVVDGRNIWAN
DFAASLSTLQALEGIVGKDKLVVSTSCSLLHTAVDLINETKLDDEIKSWM
AFAAQKVVEVNALAKALAGQKDEALFSANAAALASRRSSPRVTNEGVQKA
AAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTVELREDYV
KAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGW
VQSYGSRCVKPPVIYGDVSRPKAMTVFWSAMAQSMTSRPMKGMLTGPVTI
LNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALREGLP
LRKSEHAFYLDWAVHSFRITNCGVQDSTQIHTHMCYSHFNDIIHSIIDMD
ADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSSEEIADR
VNKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKNMVDAAKLIRSQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1u22 Chain A Residue 767 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1u22 Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
Resolution2.65 Å
Binding residue
(original residue number in PDB)		H658 D662
Binding residue
(residue number reindexed from 1)		H644 D648
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0008705 methionine synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0010043 response to zinc ion
GO:0032259 methylation
GO:0071266 'de novo' L-methionine biosynthetic process
Cellular Component
GO:0000325 plant-type vacuole
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009506 plasmodesma
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0048046 apoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1u22, PDBe:1u22, PDBj:1u22
PDBsum1u22
PubMed15326182
UniProtO50008|METE1_ARATH 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 (Gene Name=MS1)

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