Structure of PDB 1u0h Chain A Binding Site BS02

Receptor Information

>1u0h Chain A (length=189) Species: 9615 (Canis lupus familiaris)

MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL
AAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREM
TGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRI
HITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1u0h Chain A Residue 582

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1u0h Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): D396 I397 E398 D440
• Binding residue (residue number reindexed from 1): D20 I21 E22 D64
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D396 I397 D440 H516
• Catalytic site (residue number reindexed from 1): D20 I21 D64 H140
• Enzyme Commision number: 4.6.1.1: adenylate cyclase.

Gene Ontology

Molecular Function

• GO:0016849 phosphorus-oxygen lyase activity

Biological Process

• GO:0009190 cyclic nucleotide biosynthetic process
• GO:0035556 intracellular signal transduction

External links

• PDB: RCSB:1u0h, PDBe:1u0h, PDBj:1u0h
• PDBsum: 1u0h
• PubMed: 15591060
• UniProt: P30803|ADCY5_CANLF Adenylate cyclase type 5 (Gene Name=ADCY5)