Structure of PDB 1ttu Chain A Binding Site BS02

Receptor Information

>1ttu Chain A (length=435) Species: 6239 (Caenorhabditis elegans)

VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTEQQATELVAYIGIGSDTSERQQLDFPNIYDYC
AAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKQS
MKNTDCKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHASSTKWGAF
TIHLFDDERGLQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVD
KQQVILDASCSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINE
HRHQINDGAAWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGE
ASRVELHGRDFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTH
WMFTNRTTGDVEVPISLVRDDGVVYSSGLTFSYKS

Ligand information

>1ttu Chain C (length=15)

aatctttcccacagt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ttu Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): K227 Y229 S367 K368 S370 K372 K373 Q374 R399 Q401
• Binding residue (residue number reindexed from 1): K33 Y35 S142 K143 S145 K147 K148 Q149 R174 Q176

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:1ttu, PDBe:1ttu, PDBj:1ttu
• PDBsum: 1ttu
• PubMed: 15297877
• UniProt: V6CLJ5|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)