Structure of PDB 1tl7 Chain A Binding Site BS02

Receptor Information

>1tl7 Chain A (length=189) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKL
AAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREM
TGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRI
HITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

1tl7 Chain A Residue 582 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1tl7 Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	D396 I397 D440
Binding residue (residue number reindexed from 1)	D20 I21 D64
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D396 I397 D440 H516
Catalytic site (residue number reindexed from 1)	D20 I21 D64 H140
Enzyme Commision number	4.6.1.1: adenylate cyclase.

Gene Ontology

	Molecular Function
GO:0016849	phosphorus-oxygen lyase activity

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:1tl7, PDBe:1tl7, PDBj:1tl7
PDBsum	1tl7
PubMed	15591060
UniProt	P30803\|ADCY5_CANLF Adenylate cyclase type 5 (Gene Name=ADCY5)

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