Structure of PDB 1tj5 Chain A Binding Site BS02

Receptor Information

>1tj5 Chain A (length=244) Species: 1148 (Synechocystis sp. PCC 6803)

MRQLLLISDLDNTWVGDQQALEHLQEYLGDRRGNFYLAYATGRSYHSARE
LQKQVGLMEPDYWLTAVGSEIYHPEGLDQHWADYLSEHWQRDILQAIADG
FEALKPQSPLEQNPWKISYHLDPQACPTVIDQLTEMLKETGIPVQVIFSS
GKDVDLLPQRSNKGNATQYLQQHLAMEPSQTLVCGDSGNDIGLFETSARG
VIVRNAQPELLHWYDQWGDSRHYRAQSSHAGAILEAIAHFDFLS

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1tj5 Chain A Residue 246

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1tj5 The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): D9 T41 G42 K163 N189
• Binding residue (residue number reindexed from 1): D9 T41 G42 K163 N189
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.24: sucrose-phosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding
• GO:0050307 sucrose-phosphate phosphatase activity

Biological Process

• GO:0005986 sucrose biosynthetic process

External links

• PDB: RCSB:1tj5, PDBe:1tj5, PDBj:1tj5
• PDBsum: 1tj5
• PubMed: 15937230
• UniProt: P74325