Structure of PDB 1t8e Chain A Binding Site BS02

Receptor Information
>1t8e Chain A (length=698) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFGAYLDALEAEV
ARGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHS
NLKDTDMGLLRSGKLPGALEAWGYRLGEMKGEYKDDFKRMLEEQGEEYVD
GMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSELLRK
LTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKTPKVGGIFKKPKNKAQ
REGREPCELDTREYVAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWVPTKY
TDKGAPVVDDEVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAW
LRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCRAAFG
AEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFDNGEYAHEILNGDIH
TKNQIAAELPTRDNAKTFIYGFLYGAGDEKIGQIVGAGKERGKELKKKFL
ENTPAIAALRESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRKVHVRSP
HAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEI
QVGCRTEEIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAICH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t8e Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase.
Resolution2.54 Å
Binding residue
(original residue number in PDB)		K299 K300 S337 S338 H341 Q393 G402 D403 K404 A425 V426 T431 H432 A433 N436 Q439 G527 Y530 A532 G533 W579 R604 H607 N611 Q615
Binding residue
(residue number reindexed from 1)		K293 K294 S331 S332 H335 Q387 G396 D397 K398 A419 V420 T425 H426 A427 N430 Q433 G521 Y524 A526 G527 W573 R598 H601 N605 Q609
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006302 double-strand break repair
GO:0039693 viral DNA genome replication
GO:0090592 DNA synthesis involved in DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1t8e, PDBe:1t8e, PDBj:1t8e
PDBsum1t8e
PubMed15297882
UniProtP00581|DPOL_BPT7 DNA-directed DNA polymerase (Gene Name=5)

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