Structure of PDB 1sze Chain A Binding Site BS02
Receptor Information
>1sze Chain A (length=392) Species:
4932
(Saccharomyces cerevisiae) [
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GETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGAN
DEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATAL
CKLGNPLEGEKDVARGCGQGVTKVPQMISTAASCSPEEIIEAAPSDKQIQ
WYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFAS
RALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVSGVV
LSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGTDVL
KALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLGVTS
IAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
Ligand information
Ligand ID
173
InChI
InChI=1S/C8H6O3/c9-7(8(10)11)6-4-2-1-3-5-6/h1-5H,(H,10,11)
InChIKey
FAQJJMHZNSSFSM-UHFFFAOYSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1ccc(cc1)C(=O)C(=O)O
CACTVS 3.341
OC(=O)C(=O)c1ccccc1
ACDLabs 10.04
O=C(C(=O)O)c1ccccc1
Formula
C8 H6 O3
Name
BENZOYL-FORMIC ACID;
OXO(PHENYL)ACETIC ACID
ChEMBL
CHEMBL950
DrugBank
DB02279
ZINC
ZINC000001529359
PDB chain
1sze Chain A Residue 5580 [
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Receptor-Ligand Complex Structure
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PDB
1sze
Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
Y143 Y254 H373 R376
Binding residue
(residue number reindexed from 1)
Y44 Y155 H254 R257
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
S228 Y254 T280 D282 K349 H373
Catalytic site (residue number reindexed from 1)
S129 Y155 T181 D183 K230 H254
Enzyme Commision number
1.1.2.3
: L-lactate dehydrogenase (cytochrome).
Gene Ontology
Molecular Function
GO:0016491
oxidoreductase activity
GO:0020037
heme binding
View graph for
Molecular Function
External links
PDB
RCSB:1sze
,
PDBe:1sze
,
PDBj:1sze
PDBsum
1sze
PubMed
15260495
UniProt
P00175
|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)
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