Structure of PDB 1shz Chain A Binding Site BS02

Receptor Information
>1shz Chain A (length=326) Species: 10090,10116 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AREVKLLLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSNVIKG
MRVLVDAREKLHIPWGDNKNQLHGDKLMAFDTRAPMAAQGMVETRVFLQY
LPAIRALWEDSGIQNAYDRRREFQLGESVKYFLDNLDKLGVPDYIPSQQD
ILLARRPTKGIHETHFTFKDLHFKMFDVGGQRSERKKWFECFEGVTAIIF
CVALSDYDQVLMEDRQTNRMHESMKLFDSICNNKWFTDTSIILFLNKKDL
FEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHF
TCATDTKNVQFVFDAVTDVIIKNNLK
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain1shz Chain A Residue 378 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1shz Structure of the p115RhoGEF rgRGS domain-Galpha13/i1 chimera complex suggests convergent evolution of a GTPase activator.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		G57 E58 K61 R200 T203 G225
Binding residue
(residue number reindexed from 1)		G12 E13 K16 R155 T158 G180
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E58 T63 R200 D222 Q226
Catalytic site (residue number reindexed from 1) E13 T18 R155 D177 Q181
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1shz, PDBe:1shz, PDBj:1shz
PDBsum1shz
PubMed15665872
UniProtP10824|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1);
P27601|GNA13_MOUSE Guanine nucleotide-binding protein subunit alpha-13 (Gene Name=Gna13)

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