Structure of PDB 1rpu Chain A Binding Site BS02

Receptor Information
>1rpu Chain A (length=138) Species: 39443 (Carnation Italian ringspot virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTREQANGERWDGGSGGITSPFKLPDESPSWTEWRLYNDENPLGFKESWG
FGKVVFKRYLRYDRTEASLHRVLGSWTGDSVNYAASRFLGANQVGCTYSI
RFRGVSVTISGGSRTLQHLCEMAIRSKQELLQLTPVEV
Ligand information
>1rpu Chain D (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cguacgcgucacgcguacguu
.....................
Receptor-Ligand Complex Structure
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PDB1rpu Size selective recognition of siRNA by an RNA silencing suppressor
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R18 P37 W39 W42 K60 Y73 Q107 V108 G109 G125 G126
Binding residue
(residue number reindexed from 1)		R10 P29 W31 W34 K46 Y59 Q93 V94 G95 G111 G112
Binding affinityPDBbind-CN: Kd=0.17nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0044423 virion component

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Biological Process
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Cellular Component
External links
PDB RCSB:1rpu, PDBe:1rpu, PDBj:1rpu
PDBsum1rpu
PubMed14697199
UniProtQ66104|P19_CIRV RNA silencing suppressor p19 (Gene Name=ORF4)

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