Structure of PDB 1rm8 Chain A Binding Site BS02

Receptor Information

>1rm8 Chain A (length=169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYS
ELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD
SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMET
DNFKLPNDDLQGIQKIYGP

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

1rm8 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	1rm8 Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	H193 D195 H208 H221
Binding residue (residue number reindexed from 1)	H70 D72 H85 H98
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H246 E247 H250 H256
Catalytic site (residue number reindexed from 1)	H123 E124 H127 H133
Enzyme Commision number	3.4.24.-

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:1rm8, PDBe:1rm8, PDBj:1rm8
PDBsum	1rm8
PubMed	14741217
UniProt	P51512\|MMP16_HUMAN Matrix metalloproteinase-16 (Gene Name=MMP16)

[Back to BioLiP]