Structure of PDB 1rfi Chain A Binding Site BS02

Receptor Information

>1rfi Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWL
VKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGT
HHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHK
SGESPTHFKANLISYLTAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGR
FQGSQKDNWGHFRLKKLLKDHASSMSWPVVGQFSSVGSLGADESKWLCSE
FKESMLTLGVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHS
YFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGAL
EKNGTQLMIRSYELGVLFLPSALGLDSFKVKQKFATFPVPYDLPPELYGS
KDRPWIWNIPYVKAPDTHGNMWVPS

Ligand information

>1rfi Chain C (length=5) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KLNYK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1rfi Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	Y204 C205 F206 D230 G458 S459 P461 H493 W590
Binding residue (residue number reindexed from 1)	Y43 C44 F45 D69 G283 S284 P286 H318 W407

Enzymatic activity

Enzyme Commision number

3.1.4.-

Gene Ontology

	Molecular Function
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1rfi, PDBe:1rfi, PDBj:1rfi
PDBsum	1rfi
PubMed	14761185
UniProt	Q9NUW8\|TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 (Gene Name=TDP1)

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